"NIH's Ad Bax Takes NMR Spectroscopy to New Dimensions"

Over the past decade, analyzing the structure of proteins has become considerably more than an academic pursuit. Pharmaceutical companies now routinely employ a protein-structure group, with the goal of elucidating the structure and properties of proteins relevant to their drug-development programs. But until recently the only way to determine a protein's structure was first to crystallize it and then analyze the diffraction pattern of X-rays passing through the crystal. While nuclear magnetic resonance (NMR) could be used to determine protein structure, it appeared until early in this decade that the method could succeed only with the very smallest proteins. That a protein such as interferon-(gamma) could be studied by NMR seemed unimaginable-until it was done and published in 1992 by a team of researchers led by Ad Bax of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health IH), Bethesda, Maryland. Bax has been the driving force behind a revolutionary use of NMR to reveal the structure of proteins...
[read complete interview]

View the record of Ad Bax in ISIHighlyCited.com.

in-cites.com, ESI-Topics.com, and ScienceWatch.com are editorial components of Essential Science Indicators. Read more about them.