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J. Craig Venter answers a few questions
about his Fast Breaking Paper in the field of Multidisciplinary.
Article Title: Environmental genome shotgun
sequencing of the Sargasso Sea
Authors:
Venter, JC;Remington,
K;Heidelberg, JF;Halpern, AL;Rusch, D;Eisen, JA;Wu,
DY;Paulsen, I;Nelson, KE;Nelson, W;Fouts, DE;Levy,
S;Knap, AH;Lomas, MW;Nealson, K;White, O;Peterson,
J;Hoffman, J;Parsons, R;Baden-Tillson, H;Pfannkoch,
C;Rogers, YH;Smith, HO
Journal: SCIENCE
Volume: 304
Page: 66-74
Year: APR 2 2004
* Inst Biol Energy Alternat, 1901 Res Blvd,
Rockville, MD 20850 USA.
* Inst Biol Energy Alternat, Rockville, MD 20850
USA.
* Ctr Advancement Genom, Rockville, MD 20850 USA.
* Inst Genom Res, Rockville, MD 20850 USA.
* J Craig Venter Sci Fdn, Joint Technol Ctr,
Rockville, MD 20850 USA.
* Univ So Calif, Los Angeles, CA 90089 USA.
* Bermuda Biol Stn Res Inc, St George GE01, Bermuda. |
Why do you think your paper is highly cited?
The Sargasso Sea study had many
important findings from the obvious, 1.3 million new
genes and thousands of new species, to unique
environmental biology with the discovery of over
800 new photoreceptors that could help explain the rich
diversity of life in a
nutrient-poor environment. The paper also provided the
first proof that scientists can use “whole environment”
shotgun DNA sequencing to characterize complex
environments. This paper demonstrated that the methods
and algorithms that we developed for sequencing the
human and other large genomes are equally applicable to
complex mixtures of thousands of species. We have
demonstrated that within one sample dataset we could
uniquely assemble genomic DNA ranging from complete or
nearly complete genomes of abundant organisms down to
paired-end reads from organisms that are rare in the
sample.
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