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Bruce Beutler answers a few questions
about his Fast Breaking Paper in the field of Immunology.
Article
Title: Identification of Lps2 as a key transducer of
MyD88-independent TIR signalling
Authors: Hoebe, K;Du, X;Georgel, P;Janssen, E;Tabeta,
K;Kim, SO;Goode, J;Lin, P;Mann, N;Mudd, S;Crozat,
K;Sovath, S;Han, J;Beutler, B
Journal: NATURE
Volume: 424
Page: 743-748
Year: AUG 14 2003
* Scripps Res Inst, Dept Immunol, IMM-31, 10550 N
Torrey Pines Rd, La Jolla, CA 92037 USA.
* Scripps Res Inst, Dept Immunol, La Jolla, CA 92037
USA.
* La Jolla Inst Allergy & Immunol, Div Cellular
Immunol, San Diego, CA 92121 USA.
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Why do you think your paper is highly cited? 
The Toll-like receptor (TLR)
field has undergone a rapid expansion since it was
recognized in 1998 that these proteins serve as the key
sensors of microbial infection of all types. Attention
then turned to the adaptor proteins that permit signaling
from the TLRs. Our paper describes the use of random
germline mutagenesis in the mouse to identify one such
adaptor, known as TRIF, as the basis of MyD88-independent
TLR signaling. The paper filled a major gap in the field,
in that it had not been known which adaptor(s) were
responsible for signaling that occurred in the absence of
MyD88. It also showed the power of germline mutagenesis in
addressing questions of this type. Finally, ours was the
first paper to show that TLR signaling is important...[read
complete interview]
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