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Giorgio Trinchieri answers a few questions
about his Fast Breaking Paper in the field of Immunology.
Article
Title: Interleukin-12 and the regulation of innate
resistance and adaptive immunity
Authors: Trinchieri, G
Journal: NAT REV IMMUNOL
Volume: 3
Page: 133-146
Year: FEB 2003
* Schering Plough SpA, Res Inst, Lab Immunol Res, 27 Chemin Peupliers, BP 11, F-69571 Dardilly, France.
* Schering Plough SpA, Res Inst, Lab Immunol Res, F-69571 Dardilly, France.
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Why do you think your paper is highly cited? 
The paper is a
comprehensive review of the role of the cytokine
Interleukin-12 (IL-12) and of other recently described
members of the family of heterodimeric cytokines in innate
resistance and adaptive immunity. IL-12 was the first
heterodimeric cytokine to be described, and it has been
shown to play a key role in regulating both innate and
adaptive immunity. IL-12 is produced early on during
infections or inflammatory responses by phagocytic cells
and dendritic cells, the most potent antigen-presenting
cells. IL-12, acting together with other pro-inflammatory
cytokines and cell-to-cell signals, induce natural killer
(NK) cells and certain T lymphocytes to rapidly produce...
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