|
Ronald Germain answer a few questions
about his Fast Moving Front in the field of Immunology.
| "Dynamic
imaging of T cell-dendritic cell interactions in
lymph nodes," by
S;Delon, J;Brotz,
TM;Germain, RN,
SCIENCE, 296:
(5574) 1873-1876, JUN 7 2002. |
Why do you think your paper is highly cited?
Until the publication of
this paper and the accompanying papers in Science
in 2002, immunologists have had to imagine how the
critical cell-cell interactions that give rise to
adaptive immunity take place within lymphoid tissues.
They had to use static data from
stained sections of frozen or fixed samples to construct
a mental picture of the highly dynamic events involved
in activation of lymphocytes by foreign material
(antigen). This paper and two others published in the
same issue of Science provided the first "moving
pictures" of the behavior of different cell types within
lymphoid tissues. Our work in particular also helped
resolve a contentious issue, namely how long a T cell
interacts with an antigen-bearing dendritic cell. This
is thought to be a crucial parameter in the control of T
lymphocyte differentiation and could not be determined
in a physiologic tissue context by any other available
technique.
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