Valina L. Dawson discusses her new hot paper in Multidisciplinary

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Valina L. Dawson was featured in the New Hot Paper category of ESI-Topics.com
Below is an excerpt of her comment. Read the complete article.

September
2007

Valina L. Dawson answer a few questions
about her new hot paper in the field of Multidisciplinary.

Article Title: "Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor"
Authors: Yu, SW;Wang, HM;Poitras, MF;Coombs, C;Bowers, WJ;Federoff, HJ;Poirier, GG;Dawson, TM;Dawson, VL
Journal: SCIENCE left to right - Ted M. Dawson and Valina L. Dawson
Volume: 297
Page: 259-263
Year: JUL 12 2002
* Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA.
* Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA.
* Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21287 USA.
* Johns Hopkins Univ, Sch Med, Dept Physiol, Baltimore, MD 21287 USA.
* Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21287 USA.
* Univ Rochester, Ctr Aging & Dev Biol, Dept Neurol, Rochester, NY 14642 USA.
* Univ Laval, Med Res Ctr, CHUQ, Hlth & Environm Unit, St Foy, PQ G1V 4G2, Canada.

Why do you think your paper is highly cited?

PARP-1 (Poly-ADP Ribose Polymerase) dependent cell death is critically important in a number of experimental disease models including diabetes, inflammation, arthritis, myocardial infarction, Parkinson’s disease, and cerebral ischemia. The mechanism of PARP-1-dependent cell death has been proposed to be due to energy depletion; however, data supporting this hypothesis is not conclusive. Our paper identifies an alternate cell death program involving apoptosis-inducing factor (AIF). We and others have been observing cell death that utilizes some, but not all, of the death machinery described in models of classic apoptosis. In some cases, investigators observed what appeared to be caspase-independent cell death. Some argued that the relevant caspase had just not yet been discovered, while others questioned whether there might be other specialized forms of cell death beyond the dichotomy of necrosis or apoptosis. In the nervous system this is quite important. There have been many disparate observations made in excitotoxicity and experimental...
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